![]() A nonreactive NST had a 77.8% positive predictive value (95% CI 49.0–100) in identifying the need for neonatal transfusion. The mean (standard error of the mean range) hematocrit (%) at birth was 38.9 (3.0 21.3–52.0) in patients with reactive NSTs and 28.3 (3.8 14.5–45.0) in those with nonreactive NSTs ( P <. Twelve of 51 (23.5%) patients with reactive NSTs and seven of nine (77.8%) patients with nonreactive NSTs required neonatal transfusion ( P =. Fifty-one patients (85%) had reactive NSTs until delivery, and nine (15%) had nonreactive NSTs that prompted delivery. Sixty patients with isoimmunization were identified during the study period. Neonatal outcome data were obtained prospectively and by chart review. Results of the last NST before delivery were analyzed. ![]() Nonstress tests were interpreted as either reactive or nonreactive using standard criteria. #Giuliana songster md serial#In addition to prenatal care, serial ultrasonography, and invasive testing when indicated, patients had NSTs two times per week. We retrospectively reviewed the records of all patients evaluated for isoimmunization in pregnancy for the period January 1992 to December 1994. (Am J Obstet Gynecol 2000 182:313-20.To assess the value of the fetal nonstress test (NST) in predicting neonatal transfusion in pregnancies complicated by red cell isoimmunization. Increasing hyperglycemia at diagnosis or presentation for care was associated with an increasing risk of anomalies in general and with anomalies involving multiple organ systems without a preferential increase in involvement of specific organ system. Conclusion: Congenital anomalies in offspring of women with gestational and type 2 diabetes affect the same organ systems that have been previously described in pregnancies complicated by type 1 diabetes. 04) or no organ systems were affected (115 ± 38 mg/dL, P <. Pregnancies with major anomalies affecting multiple organ systems had significantly higher initial fasting serum glucose levels (166 ± 64 mg/dL) compared with pregnancies in which one organ system was affected (141 ± 55 mg/dL, P <. There was no increased predominance of any specific organ system involvement seen with increasing fasting serum glucose levels in pregnancies with major congenital anomalies. Of those pregnancies with major anomalies, the most commonly affected organ systems were the cardiac (37.6%), musculoskeletal (14.7%), and central nervous systems (9.8%) and anomalies involving multiple organ systems (16%). Results: The initial fasting serum glucose and glycosylated hemoglobin levels were significantly higher in pregnancies with major (n = 143) and minor (n = 112) anomalies and genetic syndromes (n = 9) compared with pregnancies with no anomalies (n = 3895). In addition to maternal clinical and historical parameters, the initial fasting serum glucose either from the diagnostic glucose tolerance test (gestational diabetes mellitus) or at entry to prenatal care (type 2 diabetes) and the initial glycosylated hemoglobin before insulin therapy were examined for a relationship to anomalies. Major anomalies were further categorized by the number and type of affected organ systems. ![]() Anomalies were categorized as being absent, minor, major, genetic syndromes, or aneuploidies. ![]() Study Design: A total of 4180 pregnancies complicated by gestational diabetes mellitus (n = 3764) or type 2 diabetes (n = 416) that were delivered after 20 weeks of gestation were reviewed for the presence of congenital malformations diagnosed before hospital discharge. Objectives: We sought to determine the types of congenital anomalies affecting infants of women with gestational diabetes mellitus or type 2 diabetes and to examine the relationship between those malformation types and measures of initial glycemia of women at entry into prenatal care with type 2 diabetes or at time of diagnosis in women with gestational diabetes mellitus. ![]()
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